Calorie restriction and longevity
Evidence on calorie restriction spans animal studies and human trials; changes in biological markers are not proof of longer human lifespan.
Scientific sources and reference guidelines
A selection of scientific references and guidelines on Calorie restriction and longevity. The list is not exhaustive and may be updated over time.
- Colman et al., Science (2009) — PMID 19590001 — Wisconsin rhesus macaque study reporting lower age-related mortality and disease; animal evidence, not directly transferable to humans.
- Colman et al., Nature Communications (2014) — PMID 24691430 — Wisconsin study follow-up: rhesus macaques on calorie restriction showed lower age-related and all-cause mortality; preclinical findings.
- Mattison et al., Nature (2012) — PMID 22932268 — NIA macaque study: no significant survival increase was detected at the reported analysis; diet and control design differed from Wisconsin.
- Mattison et al., Nature Communications (2017) — PMID 28094793 — Comparison of the primate studies: age at onset, diet and controls help explain differing outcomes; this is not a human trial.
- Ravussin et al., CALERIE-2 (2015) — PMID 26187233 — Two-year randomized human trial of a prescribed 25% restriction; it assessed feasibility and health indicators, not lifespan.
- Waziry et al., CALERIE / DunedinPACE (2023) — PMID 37118425 — Post hoc analysis: DunedinPACE slowed by 2–3%; PhenoAge and GrimAge clocks did not change significantly, and lifespan outcomes were not measured.
- Fontana & Partridge, Cell (2015) — PMID 25815989 — Review comparing model organisms and human studies; it highlights the limits of transferring animal longevity findings to people.
The listed sources represent the main references on which Cibus AI is trained and updated. The list is constantly evolving and is not exhaustive. Cibus AI is a support tool and does not replace clinical, professional or ethical judgment: every decision remains the full and exclusive responsibility of the professional.
Frequently asked questions
What does the evidence say about Calorie restriction and longevity?
This page summarizes selected studies and guidelines on Calorie restriction and longevity. Evidence types and certainty vary; no single source proves effectiveness for every population or clinical situation.
Which sources does Cibus AI rely on for Calorie restriction and longevity?
Cibus AI relies on clinical guidelines, international standards and reference scientific literature for Calorie restriction and longevity, listed on this page and continuously updated.
Does Cibus AI replace clinical judgment?
No. Cibus AI is a support tool: every decision remains the full and exclusive responsibility of the professional.
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